Sleep promoting effects of BR-16A: interaction with GABAergic modulators

The aim of the present study was to investigate the sleep promoting effect of BR-16A, a polyherbal formulation along with GABAergic drugs. Pentobarbitone-induced hypnosis test was used as an animal model to explore its role in sleep. Pentobarbitone produces quick the sleep latency (onset) and prolongation of total sleep time (duration). Seep latency and total sleep time were used as parameters for the evaluation. BR-16A potentiated the effect of triazolam (0.1 mg/kg, ip) and alprazolam (0.25 mg/kg, ip). Melatonin (5.0 mg/kg, i.p.) and zolpidem (0.5 mg/kg, i.p.) did not produce any significant effect on sleep parameters (P